有机化学oRCAnI©cIem1STY 盖讲:王德儒87092829(0) 理学院寇化素理科楼2层06 Organic Chemistry,6th Edition L.G.Wade,Jr. Chapter6 Stereochemistry
Chapter 6 Stereochemistry Organic Chemistry, 6th Edition L. G. Wade, Jr. 有机化学ORGANIC CHEMISTRY 主讲:王俊儒 87092829(O) 理学院应化系理科楼2层C206
Content Molecular Chirality Chiral carbon Absolute and Relative Configuration Stereoisomers without chiral carbons Properties of Enantiomers Diastereomers Resolution of Enantiomers Key Notes Chiralenantiomers;Chirality e Chiralcenter;Optical rotations;R/S,①/L,①iastereomers;meso forms; Resolution of enantiomers; Homework:6-226-23:16-24(P219
Content ❖Molecular Chirality & Chiral carbon ❖Absolute and Relative Configuration ❖Stereoisomers without chiral carbons ❖Properties of Enantiomers & Diastereomers ❖Resolution of Enantiomers Key Notes Chiral enantiomers; Chirality & Chiral center; Optical rotations; R /S ,D/L; Diastereomers ; meso forms; Resolution of enantiomers; Homework:6-22; 6-23:1; 6-24; (P219)
Sec 1 Chirality Handedness":right glove doesn't fit the left hand. Mirror-image object is different from the original object. right hand left hand Copyright2005 Pearson Prentice Hall.Inc
Sec 1 Chirality ❖“Handedness”: right glove doesn’t fit the left hand. ❖Mirror-image object is different from the original object
Chirality A molecule is chiral if its two mirror image forms are not superposable upon one another. A molecule is achiral if its two mirror image forms are superposable. ◆ left hand ◆ right hand plus mitten plus mittne left hand ◆ right hand ◆ plus left glove■ plus right glove ◆ ◆ ● ◆ ◆ ◆ ■ left hand right hand left hand right hand plus right glove ◆ plus left glove plus mug plus mug
Chirality ❖A molecule is chiral if its two mirror image forms are not superposable upon one another. ❖A molecule is achiral if its two mirror image forms are superposable
Bromochlorofluoromethane is chiral It cannot be superposed point for point on its mirror image. Br 7 To show nonsuperposability,rotate this model 180 around a vertical axis
Br Cl H F Bromochlorofluoromethane is chiral H Cl Br F To show nonsuperposability, rotate this model 180° around a vertical axis. ❖It cannot be superposed point for point on its mirror image
Bromochlorofluoromethane is chiral Br 11111111111111111111
Br Cl H F Bromochlorofluoromethane is chiral H Cl Br F
Enantiomers nonsuperposable mirror images are called enantiomers and are enantiomers with respect to each other
are enantiomers with respect to each other and nonsuperposable mirror images are called enantiomers Enantiomers