1.What are some of the advantages and disadvantages of random screening? 2.What potential problems arise when using bioisosteric replacements for lead modification? 3.Briefly describe the basis for Kuntz's DOCK program and Cramer's CoMFA. 4.Steric,electronic,lipophilic,and H-bonding effects are important parameters of molecules employed in computer-aided drug design.Why are each of these effects important in drug design?
1. What are some of the advantages and disadvantages of random screening? 2. What potential problems arise when using bioisosteric replacements for lead modification? 3. Briefly describe the basis for Kuntz’s DOCK program and Cramer’s CoMFA. 4. Steric, electronic, lipophilic, and H-bonding effects are important parameters of molecules employed in computer-aided drug design. Why are each of these effects important in drug design?