1.The reasons why utilize a prodrug strategy in drug design. 2.The difference among bipartite,tripartite and mutual prodrugs. 3.The cornea has significant esterase activity.Epinephrine is an antiglaucoma agent that does not penetrate the cornea well.Suggest a prodrug (other than one used for epinephrine in the text). 4.Draw a mutual prodrug for antitumor agents having different mechanism of action
1. The reasons why utilize a prodrug strategy in drug design. 2. The difference among bipartite, tripartite and mutual prodrugs. 3. The cornea has significant esterase activity. Epinephrine is an antiglaucoma agent that does not penetrate the cornea well. Suggest a prodrug (other than one used for epinephrine in the text). 4. Draw a mutual prodrug for antitumor agents having different mechanism of action
