1.What are the drugs biotranformation,phase I and phase II reactions? 2.Show all of the steps(not the mechanisms)of this metabolic pathway,and note over each arrow used in your scheme the general types of enzymes involved. CH3 CH; 0 0 COOH NH, CH3 3.The antiestrogen drug toremifene is metabolized into six major metabolites.Draw six reasonable metabolites for this drug,and note over each arrow what kind of reaction and enzyme are involved. CH3 CH3 CI 4.Which of the following hypothetical metabolic reactions are phase I and which are phase II?Name the reactions,and note the cofactors(no mechanisms needed)
1. What are the drugs biotranformation, phase I and phase II reactions? 2. Show all of the steps (not the mechanisms) of this metabolic pathway, and note over each arrow used in your scheme the general types of enzymes involved. N O O CH3 CH3 NH2 O COOH CH3 3. The antiestrogen drug toremifene is metabolized into six major metabolites. Draw six reasonable metabolites for this drug, and note over each arrow what kind of reaction and enzyme are involved. Cl O N CH3 CH3 4. Which of the following hypothetical metabolic reactions are phase I and which are phase II? Name the reactions, and note the cofactors (no mechanisms needed)
NH? OH -0 OH COOH CH
N S N Cl CH3CH3 N S NH2 Cl N S H Cl O a. b. c. j e. N S NH2 Cl HO N S OH Cl N S OH Cl O N S NH2 Cl O i. SO3 - N S NH2 Cl HO HO N H S Cl HO HO h N S O Cl O OH OH OH COOH N S NH Cl O COOH N S NH2 Cl H3CO HO N S NH Cl H3CO HO CH3 O N S NH2 Cl H3CO HO O f. k. d. g. m l