1.Please illuminate the general classification of alkylating agents,topoisomerase II inhibitors, antimetabolic agents,microtubule-targeting agents. 2.Please demonstrate the mechanism of action of nitrogen mustards,aziridines-mediated alkylators,nitrosoureas,platinum complexes. 3.Can you specify the biosynthesis of dTMP,AMP,and GMP? 4.Please demonstrate the SAR of podophyllotoxin,and taxane. 5.Please review the unmet medical needs and new research areas of anticancer drugs
1. Please illuminate the general classification of alkylating agents, topoisomeraseⅡinhibitors, antimetabolic agents, microtubule- targeting agents. 2. Please demonstrate the mechanism of action of nitrogen mustards, aziridines-mediated alkylators, nitrosoureas, platinum complexes. 3. Can you specify the biosynthesis of dTMP, AMP, and GMP? 4. Please demonstrate the SAR of podophyllotoxin, and taxane. 5. Please review the unmet medical needs and new research areas of anticancer drugs